This course from pharmaceutical chemistry domain provides a comprehensive overview of the key concepts of medicinal chemistry. Course will comprise of basic principles of drug designing and eventually with more emphasis on structural activity relationship (SAR) of molecules that are pharmaceutically important. Course will also cover basic principles of in silico drug designing. It aims to explain the synthesis of different classes of drugs and their pharmacophores.


CLO: 1. To describe the structural activity relationship (SAR) of different pharmacophores
CLO: 2. To illustrate principles and steps for synthesis of different classes of drugs, and their use,
CLO: 3. To apply knowledge of basic concepts of medicinal chemistry for designing of different pharmacophores


General properties, chemistry biological action, structure activity relationship and therapeutic applications of following:

  1. Sulphonamides:
    • Prontosil, sulphanilamide, Sulphapyridine, sulphadimidine, Sulfamethoxazole, Sulfadiazine and Sulfafurazole.
  2. Antimalarials:
    • 4-Aminoquinolines, 8-Aminoquinolines, 9-Amino acridines, Biguanides, Pyrimidine analogues, Mefloquine and Cinchona alkaloids.
  3. Diuretics:
    • Mercaptomerin, Meralluride, Thiazides, Sprironolactone, Theophylline, Furosemide, Acetazolamide, Ethacrynic acid and Triameterene.
  4. Antitubercular Drugs:
    • Ethambutol, Isonicotinic acid, Hydrazid, Rifampacin, Thioguanine, Pyrazinamide, cycloserine, Ethunamide, Cytarabine, 5-Flourouracil and Dacarbazine.
  5. Antiviral Drugs:
    • Acyclovir, Tromantadine Hydrochloride and Ribavirin.
  6. Immunosuppressant Agents:
    • Azathioprine and Cyclosporin.
  7. Antibiotics:
    • Penicillins, Cephalosporins, Streptomycin, Chloramphenicol, Tetracyclines, Kanamycin and Erythromycin.